Proteins that work at the ends of DNA could provide cancer insight

ScienceDaily (Nov. 29, 2012) ? New insights into a protein complex that regulates the very tips of chromosomes could improve methods of screening anti-cancer drugs.

Led by bioengineering professor Sua Myong, the research group's findings are published in the journal Structure.

Myong's group focused on understanding the proteins that protect and regulate telomeres, segments of repeating DNA units that cap the ends of chromosomes. Telomeres protect the important gene-coding sections of DNA from loss or damage, the genetic equivalent of aglets -- the covering at the tips of shoelaces that keep the ends of the laces from unraveling or fraying.

Telomeres play an important role in cell aging and death, since each time a cell divides, a little bit is lost from the end of the telomere. Thus, cell biologists postulate that telomere length can determine the lifespan of a cell. Cancer cells, however, have a way to get around this limitation: An enzyme called telomerase that adds length to telomeres is highly active in cancer cells. This allows cancer cells to divide in perpetuity, running amok through tissues and systems.

"Cancer researchers want to get a hold of this problem, control this indefinite lengthening of the telomeres," said Myong, who also is affiliated with the Institute for Genomic Biology at the U. of I. "A lot of the anti-cancer drugs are targeted directly to these telomeres so that they can inhibit telomerase activity. The proteins we study regulate the activity of telomerase."

Using a technique developed at Illinois that allows researchers to watch single molecules interact in real time, Myong's group determined how two proteins called POT-1 and TTP-1 bind to the telomere. POT-1 protects the fragile telomere ends from being attacked by other regulatory proteins that might mistake the end for a broken or damaged area of DNA. When POT-1 and TTP-1 work together in a complex, they promote telomerase activity, an interesting target for cancer researchers.

The group found that on its own, POT-1 binds to the folded-up telomere in distinct steps at particular points in the telomere's DNA sequence, unfolding the telomere in a stepwise manner. However, the POT-1/TTP-1 complex surprised the researchers by binding, then freely sliding back and forth along the telomere end.

"Instead of stepwise binding, what we saw was a mobile protein complex, a dynamic sliding motion," Myong said. "Somehow it was as if the static binding activity of POT-1 is completely lost -- the protein complex just slid back and forth. We were able to reproduce the data and confirm it with many different tail lengths of the telomeric DNA and we know now that the contact between POT-1 and the telomere is somehow altered when the partner protein comes and binds."

Next, the researchers will add telomerase and see how the sliding activity of the POT-1/TTP-1 complex affects telomerase activity. Myong postulates that the sliding may promote telomerase activity -- and thus telomere lengthening -- by making the end of the telomere accessible for the telomerase enzyme to bind.

"We are excited about the possibility that this kind of mobility can increase the telomerase extension activity," Myong said. "It's somehow engaging the enzyme so that it can stay bound to the DNA longer. So it must involve a direct interaction."

Ultimately, understanding the POT-1/TTP-1 complex gives drug developers a new target for anti-cancer drugs, and the assay Myong's group used to monitor the complex could offer a venue for evaluating telomere-targeting drugs.

"We want to extend our a basic science knowledge in telomere biology into causes of cancer and we hope that our assay can be useful for telomere-targeted drug screening," Myong said.

The American Cancer Society and the Human Frontier Science Research Program supported this work.

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The above story is reprinted from materials provided by University of Illinois at Urbana-Champaign.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. Helen Hwang, Noah Buncher, Patricia?L. Opresko, Sua Myong. POT1-TPP1 Regulates Telomeric Overhang Structural Dynamics. Structure, 2012; 20 (11): 1872 DOI: 10.1016/j.str.2012.08.018

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/H7VyF-YvzO4/121129152029.htm

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What You Can Do With a $550 Million Powerball Jackpot

Are you going to win the $550 million pot? Statistics aside, you feel almost 100% certain that you will. Now is the time to start wrapping your brain around just how much cash that is. More »

Source: http://feeds.gawker.com/~r/gizmodo/full/~3/si34bs9N7xs/what-you-can-do-with-a-500-million-powerball-jackpot

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Precisely engineering 3-D brain tissues

ScienceDaily (Nov. 29, 2012) ? Borrowing from microfabrication techniques used in the semiconductor industry, MIT and Harvard Medical School (HMS) engineers have developed a simple and inexpensive way to create three-dimensional brain tissues in a lab dish.

The new technique yields tissue constructs that closely mimic the cellular composition of those in the living brain, allowing scientists to study how neurons form connections and to predict how cells from individual patients might respond to different drugs. The work also paves the way for developing bioengineered implants to replace damaged tissue for organ systems, according to the researchers.

"We think that by bringing this kind of control and manipulation into neurobiology, we can investigate many different directions," says Utkan Demirci, an assistant professor in the Harvard-MIT Division of Health Sciences and Technology (HST).

Demirci and Ed Boyden, associate professor of biological engineering and brain and cognitive sciences at MIT's Media Lab and McGovern Institute, are senior authors of a paper describing the new technique, which appears in the Nov. 27 online edition of the journal Advanced Materials. The paper's lead author is Umut Gurkan, a postdoc at HST, Harvard Medical School and Brigham and Women's Hospital.

'Unique challenges'

Although researchers have had some success growing artificial tissues such as liver or kidney, "the brain presents some unique challenges," Boyden says. "One of the challenges is the incredible spatial heterogeneity. There are so many kinds of cells, and they have such intricate wiring."

Brain tissue includes many types of neurons, including inhibitory and excitatory neurons, as well as supportive cells such as glial cells. All of these cells occur at specific ratios and in specific locations.

To mimic this architectural complexity in their engineered tissues, the researchers embedded a mixture of brain cells taken from the primary cortex of rats into sheets of hydrogel. They also included components of the extracellular matrix, which provides structural support and helps regulate cell behavior.

Those sheets were then stacked in layers, which can be sealed together using light to crosslink hydrogels. By covering layers of gels with plastic photomasks of varying shapes, the researchers could control how much of the gel was exposed to light, thus controlling the 3-D shape of the multilayer tissue construct.

This type of photolithography is also used to build integrated circuits onto semiconductors -- a process that requires a photomask aligner machine, which costs tens of thousands of dollars. However, the team developed a much less expensive way to assemble tissues using masks made from sheets of plastic, similar to overhead transparencies, held in place with alignment pins.

The tissue cubes can be made with a precision of 10 microns, comparable to the size of a single cell body. At the other end of the spectrum, the researchers are aiming to create a cubic millimeter of brain tissue with 100,000 cells and 900 million connections.

Answering fundamental questions

Because the tissues include a diverse repertoire of brain cells, occurring in the same ratios as they do in natural brain tissue, they could be used to study how neurons form the connections that allow them to communicate with each other.

"In the short term, there's a lot of fundamental questions you can answer about how cells interact with each other and respond to environmental cues," Boyden says.

As a first step, the researchers used these tissue constructs to study how a neuron's environment might constrain its growth. To do this, they placed single neurons in gel cubes of different sizes, then measured the cells' neurites, long extensions that neurons use to communicate with other cells. It turns out that under these conditions, neurons get "claustrophobic," Demirci says. "In small gels, they don't necessarily send out as long neurites as they would in a five-times-larger gel."

In the long term, the researchers hope to gain a better understanding of how to design tissue implants that could be used to replace damaged tissue in patients. Much research has been done in this area, but it has been difficult to figure out whether the new tissues are correctly wiring up with existing tissue and exchanging the right kinds of information.

Another long-term goal is using the tissues for personalized medicine. One day, doctors may be able to take cells from a patient with a neurological disorder and transform them into induced pluripotent stem cells, then induce these constructs to grow into neurons in a lab dish. By exposing these tissues to many possible drugs, "you might be able to figure out if a drug would benefit that person without having to spend years giving them lots of different drugs," Boyden says.

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The above story is reprinted from materials provided by Massachusetts Institute of Technology, via EurekAlert!, a service of AAAS. The original article was written by Anne Trafton.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. Umut Atakan Gurkan, Yantao Fan, Feng Xu, Burcu Erkmen, Emel Sokullu Urkac, Gunes Parlakgul, Jacob Bernstein, Wangli Xing, Edward S. Boyden, Utkan Demirci. Simple Precision Creation of Digitally Specified, Spatially Heterogeneous, Engineered Tissue Architectures. Advanced Materials, 2012; DOI: 10.1002/adma.201203261

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_technology/~3/fUfdj_J3bHc/121129143454.htm

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Weak start to November hits some big U.S. retailers

(Reuters) - Leading U.S. retailers said weak sales in early November, when people in the Northeast were cleaning up after superstorm Sandy, dragged down results for the month, despite brisk activity over the long Thanksgiving weekend.

Target Corp and Macy's Inc, two of the biggest companies to report monthly sales on Thursday, missed analysts' expectations. Both said the weakness came at the beginning of November, not during the Thanksgiving weekend rush.

Nordstrom Inc also blamed its disappointing November sales on a lackluster first half of the month, both because of Sandy and a poor showing at its sale for women and kids.

Overall, retailers on average reported a 1.6 percent increase in sales at stores open at least a year, about half the 3.3 percent rise that analysts had forecast, according to Thomson Reuters I/B/E/S. The results include data from 16 retailers, but not drugstores. Zumiez Inc reports later on Thursday.

Same-store sales at the chains that report them are closely watched for indications of consumer spending during the beginning of the holiday season. Analysts had not expected the November results to match the 3.5 percent gain of a year earlier.

Discounts reign during the holiday season, with stores hopeful that customers who come in for deals such as Thanksgiving weekend "doorbusters" also pick up items that are not heavily marked down.

Madison Riley, managing director at retail consulting firm Kurt Salmon, said there had been "a lot of very heavy promotions" during Thanksgiving weekend.

"I think a lot of that consumer activity was focused on the doorbusters, and I don't know how much it broadened into the full store assortment," Riley said. "It may be a bit of a squeeze from a margin standpoint."

Fifty-two percent of Black Friday shoppers who participated in a Reuters/Ipsos poll said they had stayed on budget, and 34 percent said they had spent less than planned. Only 14 percent said they had gone over budget.

Despite the largest-volume Thanksgiving weekend in Macy's Inc's history, the department store operator was not able to overcome the weak start of November, Chief Executive Officer Terry Lundgren said in a statement.

While Macy's posted an unexpected same-store sales decline, the company is on track for a "very strong" performance in the current, holiday quarter, Lundgren said.

Target's 1 percent decline in same-store sales stemmed from weakness in the first two weeks of November, CEO Gregg Steinhafel said in a statement. Sales picked up later in the month, and profitability was as planned, Steinhafel added.

Limited Brands Inc said its same-store sales had risen 5 percent, including a hit of one to two percentage points from Sandy. The results topped analysts' expectations for a 3.1 percent increase.

Gap Inc's comparable sales rose 3 percent, while Wall Street was expecting a rise of 3.9 percent. However, all of the company's brands did better than last year, led by a turnaround at Old Navy, which lured shoppers on Black Friday with items such as $15 jeans and $5 fleece jackets.

HOLIDAY OUTLOOKS

Fitch Ratings said on Wednesday that it expected 2012 holiday retail sales to grow between 3 percent and 4 percent, down from a 5.6 percent increase in 2011, even though the season got off to a strong start.

The National Retail Federation still expects sales in November and December to rise 4.1 percent this year, below last year's 5.6 percent increase. Total spending was up 12.8 percent at $59.1 billion over the long Thanksgiving weekend, according to an NRF survey.

Cyber Monday deals are not a factor in retailers' November reports, as most chains are reporting their sales through Saturday, November 24. Cyber Monday, the Monday after Thanksgiving that this year fell on November 26, was reportedly the biggest online shopping day ever.

Some retailers that analysts have said did well over the weekend, such as Wal-Mart Stores Inc and online leader Amazon.com Inc, do not report monthly sales.

Same-store sales at Costco Wholesale Corp, the biggest chain that issues monthly reports, rose a better-than-expected 6 percent, the warehouse club operator said on Wednesday.

(Reporting by Jessica Wohl in Chicago; Additional reporting by Nivedita Bhattacharjee in Chicago; Editing by Lisa Von Ahn)

Source: http://news.yahoo.com/november-sales-thanksgiving-weekend-boost-130704583--finance.html

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Fujitsu's Wandant dog pedometer tracks your pet's moves, uploads ...

There's a whole host of techy tools that will let you log your 10k personal best, and break down your splits into minute detail, but what about poor old Rover? Fujistu spotted this gap, and created Wandant -- a sensor-laden neck tag for dogs complete with cloud-based service for tracking your pooch's wellbeing. The hardware will log your pet's footsteps, amount of shivering plus temperature change, and upload it automatically via your smartphone or PC. The software will present you these data over time, with the option of manually inputting further details such as food amount, a diary with photos and -- for those with stronger constitutions -- stool condition. Like human-focused equivalents, there will also be provisions for sharing your dog's efforts, but thankfully only with vets and research institutions. There's no details on hardware pricing just yet, but the online component is free for the first year (JPY 420 / about $5 per month there after). Money no object for your mutt? Sadly only available in Japan for the time being, so you'll need to include a return ticket in that splurge too.

Source: http://www.engadget.com/2012/11/28/fujitsu-wandant-dog-pedometer/

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Smartphone Study is Good News for Apple, Bad News for Canon

Apple (NASDAQ: AAPL), Samsung, Nokia (NYSE: NOK), Research In Motion (NASDAQ: RIMM) and other smartphone manufacturers can rejoice in the news that consumers are repeatedly turning to their cellular devices to perform a wide array of tasks.

According to PCMag, 82 percent of smartphone users turn on the device just to take a picture, while 80 percent turn it on to send or receive a text message. More than half (56 percent) turn it on to surf the Web; 50 percent do so to send or receive an e-mail.

These findings are not as surprising as they are damaging to companies that produce specific-use devices. Canon (NYSE: CAJ), for example, does not make cellular devices. But it produces a number of digital cameras, including several pocket-sized devices. If Consumers are reaching for their smartphones instead of an actual camera to take photos, Canon's future could be in jeopardy.

Year-to-date Canon shares are down more than 22 percent. The company experienced a few spikes during the summer months, gaining more than 12 percent. Those gains were all but diminished as investors abandoned the stock at the end of the season. They came back in September, raising Canon shares by 14 percent. Those gains were short-lived, however. In the weeks that followed, the company lost more than 17 percent of its value.

Up until this week, Canon had been experiencing another spike, rallying 15 percent since November 14. Those gains have not been able to offset the company's overall losses, however.

At the same time, Apple's shares have been indirectly enhanced by the camera featured in the iPhone. While no single stock move can be attributed to its photographic capabilities, it is no secret that millions of consumers purchased the iPhone 5 for its camera. Despite having endured a three-month decline of more than 13 percent, Apple shares are still up more than 42 percent year-to-date.

Follow me @LouisBedigianBZ

(c) 2012 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.

Tags: Apple, Canon, iPhone 5

Posted in: News, Tech, Trading Ideas, Best of Benzinga

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Source: http://www.benzinga.com/news/12/11/3127621/smartphone-study-is-good-news-for-apple-bad-news-for-canon

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Wal-Mart, Disney clothes found in Bangladesh fire

Boxes of garments lay near equipment charred in the fire that killed 112 workers Saturday at the Tazreen Fashions Ltd. factory,on the outskirts of Dhaha, Bangladesh, Wednesday, Nov. 28, 2012. Garments and documents left behind in the factory show it was used by a host of major American and European retailers, though at least one of them ? Wal-Mart ? had been aware of safety problems. Wal-Mart blames a supplier for using Tazreen Fashions without its knowledge. (AP Photo/Ashraful Alam Tito)

Boxes of garments lay near equipment charred in the fire that killed 112 workers Saturday at the Tazreen Fashions Ltd. factory,on the outskirts of Dhaha, Bangladesh, Wednesday, Nov. 28, 2012. Garments and documents left behind in the factory show it was used by a host of major American and European retailers, though at least one of them ? Wal-Mart ? had been aware of safety problems. Wal-Mart blames a supplier for using Tazreen Fashions without its knowledge. (AP Photo/Ashraful Alam Tito)

A Disney brand sweater lays among equipment charred in the fire that killed 112 workers Saturday at the Tazreen Fashions Ltd. factory, on the outskirts of Dhaha, Bangladesh, Wednesday, Nov. 28, 2012. Garments and documents left behind in the factory show it was used by a host of major American and European retailers, though at least one of them ? Wal-Mart ? had been aware of safety problems. Wal-Mart blames a supplier for using Tazreen Fashions without its knowledge. (AP Photo/Ashraful Alam Tito)

Walmart's Faded Glory label is seen on a piece of clothing laying among equipment charred in the fire that killed 112 workers Saturday at the Tazreen Fashions Ltd. factory, on the outskirts of Dhaha, Bangladesh, Wednesday, Nov. 28, 2012. Garments and documents left behind in the factory show it was used by a host of major American and European retailers, though at least one of them ? Wal-Mart ? had been aware of safety problems. Wal-Mart blames a supplier for using Tazreen Fashions without its knowledge. (AP Photo/Ashraful Alam Tito)

A Disney brand sweater lays among the equipment charred in the fire that killed 112 people Saturday at the Tazreen Fashions Ltd. factory, on the outskirts of Dhaha, Bangladesh, Wednesday, Nov. 28, 2012. Garments and documents left behind in the factory show it was used by a host of major American and European retailers, though at least one of them ? Wal-Mart ? had been aware of safety problems. Wal-Mart blames a supplier for using Tazreen Fashions without its knowledge. (AP Photo/Ashraful Alam Tito)

A piece of clothing with a label referring to German brand KIK as the buyer lays among equipment charred in the fire that killed 112 workers Saturday at the Tazreen Fashions Ltd. factory, on the outskirts of Dhaha, Bangladesh, Wednesday, Nov. 28, 2012. Garments and documents left behind in the factory show it was used by a host of major American and European retailers, though at least one of them ? Wal-Mart ? had been aware of safety problems. Wal-Mart blames a supplier for using Tazreen Fashions without its knowledge. (AP Photo/Ashraful Alam Tito)

DHAKA, Bangladesh (AP) ? The garment factory in Bangladesh where 112 people were killed in a fire had been making clothes for Wal-Mart, Disney, Sears and other major global retailers ? some of whom say they thought they had stopped doing business with the place.

The apparent confusion underscored what some industry experts say is a major obstacle to improving factory safety in developing nations: Many retailers in the U.S. and Europe rely on such a long and complex chain of manufacturers, vendors and middlemen to keep their shelves stocked that it is difficult to keep track of where certain products are made.

Amid the blackened tables and melted sewing machines at Tazreen Fashions Ltd., an Associated Press reporter discovered clothes and account books Wednesday that indicated the factory was used by a host of U.S. and European retailers.

Among the items discovered: children's shorts with Wal-Mart's Faded Glory label, hooded sweaters marked "Disney Pixar," shorts with hip-hop star Sean Combs' ENYCE tag, and sweaters from the French company Teddy Smith and the Scottish company Edinburgh Woollen Mill. Sears was among the companies listed in the account books.

The tragedy is putting a spotlight on dangerous workplace conditions around the world, with no clear answers to how consumers should react or who is ultimately responsible.

Wal-Mart said that it received a safety audit that showed the factory was "high-risk" and had decided well before the blaze to stop doing business with Tazreen. But it said a supplier had continued to use Tazreen without authorization.

When pressed for an explanation of how a supplier could use a factory without the retailer's approval and whether it happened often, Kevin Gardner, a Wal-Mart spokesman, did not directly address the issue in emails to The Associated Press.

Sears said it learned after the blaze that its merchandise was being produced there without its approval through a vendor, which has since been fired. Walt Disney Co., which licenses its characters to clothing makers, said its records indicate that none of its licensees have been permitted to make Disney-brand products at the factory for at least a year.

Retailers like Wal-Mart have contract clauses that require suppliers to disclose all factories and subcontractors producing merchandise for sale. But it's hard to crack down on unauthorized subcontracting, said Josh Green, chief executive of New York-based Panjiva, which tracks shipments for factories outside the U.S.

"The reality is you have to have round-the-clock monitoring of every aspect of the supplier's operations," he said. "It's just not feasible."

Green noted that subcontracting is pervasive as suppliers look for ways to cut costs.

"You have relentless pressure that consumers put on retailers and that retailers put on their suppliers to deliver lower and lower prices," he said. "And that pressure is a key reason why you see factories cutting corners."

Bangladesh's fast-growing garment industry ? second only to China's in exports ? has long provided jobs and revenue for the desperately poor country, while turning out the low-priced products shoppers in the U.S. and other countries have come to enjoy. But the industry has a ghastly safety record; more than 300 workers have died in garment factory fires in Bangladesh since 2006.

Labor activists have seized on the blaze ? the deadliest in Bangladesh's nearly 35-year history of exporting clothing ? to argue that retailers must insist on more stringent fire standards.

Charles Kernaghan, director of the Institute for Global Labour and Human Rights, said nothing will change unless clothing companies protect workers as vigorously as they do their brands.

"The labels are legally protected," he said. "But there are no similar laws to protect rights of the worker."

Green said some companies are more conscientious than others in selecting factories. Some pick a manufacturer and do little or no investigation, he said, while others analyze factories' past infractions and pay monthly visits.

"There's a fundamental difference between companies who do the check-the-box approach and companies who are serious about due diligence," he said.

On Wednesday, police arrested three factory officials suspected of locking in the workers who died in Saturday's blaze on the outskirts of Dhaka. Police Chief Habibur Rahman said the three will be questioned. He said the factory owner was not among those arrested.

About 1,400 people worked at the factory, about 70 percent of them women. Survivors said exit doors were locked, and a fire official said the death toll would have been much lower if the eight-story building had had an emergency exit.

The fire broke out on the ground floor, where a factory worker named Nasima said stacks of yarn and clothes blocked part of the stairway. Nasima, who uses only one name, and other workers said that when they tried to flee, managers told them to go back to their work stations.

"Everyone was screaming for help," Nasima said. "Total chaos, panic and screaming. Everyone was trying to escape and come out. I was pulling the shirt of a man. I fainted and when I woke up I found myself lying on the road outside the factory. I don't know how I survived."

Workers expressed support for the factory owner, Delwar Hossain. Mohammad Rajib said he is "a gentle man" who heeded workers when they protested for more pay and against rough treatment by some managers.

"He took action and fired some of them," he said. "He did not sack any worker. He told us: 'You are my people. If you survive, I will survive.'"

___

Associated Press writers Farid Hossain in Dhaka and Mae Anderson and Anne D'Innocenzio in New York contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2012-11-28-Bangladesh-Factory%20Fire/id-7b83cb1fd1cd4f1ca1e1b00b854a5c79

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Wild coyotes 'kind of chilling' by Wrigley Field

CHICAGO (AP) ? Wild baseball fans may be a standard sight at Wrigley Field, but a pair of wild coyotes milling around Chicago's historic ballpark ? surrounded on all sides by bars, restaurants and busy streets ? was not what one photographer was expecting on a busy Friday night.

So he quickly grabbed his camera.

"They were just kind of chilling," freelance photographer Will Byington said. "They were hanging out and not even doing much. They were kind of just checking out the scene on a Friday night in Wrigleyville. It was like they were on a date, taking a stroll."

Byington said he was shooting a concert at a bar across the street from the stadium in the Wrigleyville neighborhood, notoriously crowded and often rowdy on weekend nights, when he saw the two coyotes hanging out by the statute of former Chicago Cubs player Ernie Banks, near the ticketing area.

"It was kind of like they were looking for tickets," the 34-year-old Chicago resident laughed. "They went by the ticket window and unfortunately found it was closed, so they were ready to move onto the bar."

Wildlife ecologist Stanley Gehrt, who has extensively studied coyotes living in and around Chicago, said coyotes have been in the area for the past decade. He said the latest data shows there are at least 2,000 coyotes in Cook County, where Chicago is located.

"That's their territory. They live there," Gehrt, who works at Ohio State University, said of the unusual pair, which he said were born and raised in the city and likely live in Wrigleyville.

Byington had just a few minutes to snap his nighttime photos before the animals moved on. But he said the coyotes appeared unfazed by the honking horns and packed sidewalks. One even stepped onto a street as cabs and cars crawled by in traffic as if the coyote was "trying to figure out, do they want to eat? Or do they want to get a drink?" he said.

Byington didn't think much of his photos until he posted them online. But they started gathering attention after getting picked up on Facebook by the Cubby Bear bar where he had been working that night.

Chicago Cubs fan Dan Michaels reasons that the coyotes were likely fellow fans of the lackluster team and simply mixed up their calendars.

"My personal theory is they don't know that the Cubs play in summer," he said Wednesday as he walked by the stadium. "They picked the wrong season to wait out by the game."

Source: http://news.yahoo.com/wild-coyotes-kind-chilling-wrigley-field-225114635.html

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Expert Reveals Exactly how To Build A Website For Beginners ...

In this article I?m going to tell you how to build a website with regard to dummies and present you to a great useful resource where you can actually have a profitable website up and running by simply as soon as 3:45 this afternoon! Or..if it?s already past 3:45, literally you might have a website online inside hours!

You see, understanding how to build a website with regard to dummies is actually not hard because website developing is now easier than ever! ? It used to end up being really hard to get a website online because of all the html page nonsense that you needed to know, but now you truly don?t need to know something technical at all to use a quality professional looking web page!

One thing that you need to realize though is that if you are looking to make money online then just having a good looking internet site won?t help you achieve which, and you?ll have to take into consideration these kind of key components of generating income online:

1) Squeeze Page ? This is the first/main part of your website which is going to seize visitors name and email address so that you can follow up with them through email! It?s important to make this happen so you can nurture rapport with your subscriber and make trust, this way you should have much more success as it pertains to selling your product as well as recommendation.
2) Thank A person Page ? It is a page that you will automatically send your new members to once they have moved into their information in your form. It will just thank them as well as instruct them on what to do next! ? E.g examine their email!
Three or more) Free Gift ? You need a quality free gift such as an ebook that you can share to your subscribers. This makes people far more most likely to enter their data into the form in your page!
4) Follow Upwards Messages ? You need a series of pre-written emails which automatically send to the subscribers at arranged intervals! These can be a newsletter, or even helpful tips that you send out to your subscribers! The more you can HELP them, the higher because you?ll increase the relationship and believe in which means when you found to offer them an item you?ll have a much better reply and will likely help to make many more sales!
5) Traffic ? Traffic is your lifeblood of an web business and without it an individual with definitely are unsuccessful. It?s important to learn just how to drive traffic using different methods because once you learn, then you?re absolutely set! ? If you can learn to implement various traffic generation techniques such as article marketing, community forum marketing and compensated inclusions your business is going to be successful. I recommend getting a traffic generation guide as well as studying it.

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Individuals 5 components earlier mentioned are the KEY to managing a successful online business! ? If you use them your family will enjoy money!
So, if you need to know how to build a website for dummies, what do you do right now?
Well I have a great free ebook that can show you EXACTLY how to create a website for dummies! ? It?s called ?Create Your First Website By Three:45 This Afternoon? which is written by a A few figure per month earner you never know exactly what he is performing when it comes to making sites and running an online success businesses!

For more information about best way to create a website please visit the website.

Source: http://voooz.com/2012/11/28/expert-reveals-exactly-how-to-build-a-website-for-beginners/

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Smart WiFi Toggler for Android Learns Where Your Networks Are, Toggles Wi-Fi and Data Automatically

Android: Smart WiFi Toggler is a free utility that automatically learns where your preferred wireless networks are located, and when you approach their location, will turn on wi-fi and join those networks. When you leave GPS range, the app will turn off your phone's wi-fi radio so you don't waste battery searching for networks while you move around.

If you frequently switch between wi-fi at home or the office and 3G/4G on the go, you know it sucks to look down at your phone only to see you left wi-fi on while you're driving and your battery has suffered as a result. XDA forum member sebouh00 designed Smart WiFi Toggler to handle this problem, and once installed, the app does most of the work for you.

The app uses your phone's network location so you don't trade one battery drain (scanning for wi-fi networks) for another (scanning for GPS location), and automatically turns on and joins your preferred wi-fi networks without your intervention. The app even automatically learns where those networks are located so you don't have to program it manually.

Granted, Smart WiFi Toggler doesn't do anything that JuiceDefender or Tasker can't already do, but Smart WiFi Toggler is completely free, less complicated, and does one thing very well.

Smart WiFi Toggler | Google Play via xda-developers

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/K3857C7aFIE/smart-wifi-toggler-for-android-learns-where-your-networks-are-toggles-wi+fi-and-data-automatically

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Art auction Friday will benefit KU student with brain cancer

Today's University Daily Kansan tells the tale of Zach Graas, a KU sophomore who about a year ago discovered he had brain cancer after his right hand went numb in the shower one day.

Read the story to see what his life has been like for the last year ??chemotherapy, daily cocktails of pills, a loss of movement in his right hand. (A warning for those who'd like to be warned: There's a bit of PG-13-level language.)

You can also read a message from Graas in this Lawrence.com Final Fridays preview (you'll have to scroll down a bit) because a silent art auction Friday will help raise money for his family to pay his many medical bills.

The auction will be 5 to 9 pm. Friday in the Alton Ballroom at Pachamamas, 800 New Hampshire St.

Source: http://www2.kusports.com/weblogs/heard_hill/2012/nov/27/art-auction-friday-will-benefit-ku-stude/

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Direct Marketing Firm Wilen Direct Achieves SSAE 16 Certification ...

DEERFIELD BEACH, FL?Nov. 27, 2012?Wilen Direct, a leader and innovator in direct marketing that leverages state-of-the-art technologies such as digital and variable data imaging, has successfully completed the new Statement on Standards for Attestation Engagement (SSAE 16) and achieved SSAE 16 certification.

The SSAE 16 audit and certification determines that the company's technology, business processes, physical security, and infrastructure meet or surpass SSAE 16 standards. The standards are established by the nationally recognized Auditing Standards Board (ASB) and the American Institute of Certified Public Accountants (AICPA).

SSAE 16 provides Wilen Direct customers with assurances and validation that the company continues to provide data sensitive business sectors with the most stringent standards of operational excellence.

The SSAE 16 certification provides validation of our operational excellence and security controls. "As we continue to work closely with data sensitive industries and our customers accelerate their expansion into the Variable Data Print sector, the SSAE 16 certification further supports our commitment to protecting our customers most valuable asset?their data," said Darrin Wilen, president of Wilen Media.

"Going through a six-month evaluation and audit of our processes and security measures was a great way to show our current and future clients that we are a world-class technology based data center and production facility," adds Gregory Dean, Wilen Direct chief technology officer.

Jack Moore, CPA, CITP president of the Moore Group, also notes that successfully completing a SOC1-SSAE?16 Type?2 audit is a significant accomplishment for any organization. "The controls you have in place and continue to maintain are an excellent indication of the thought and care you've used to develop an environment that is well suited to properly serve your customers."

About Wilen Direct
Wilen Direct is an affiliated partner of the Wilen Group, a privately held marketing communications and printing services company that provides strategy, creative resources, data analysis, state-of-the-art printing and end-to-end fulfillment to a variety of clients nationwide. In addition to Wilen Direct, Wilen Group consists of two other affiliated companies, all three of which work independently but seamlessly integrate with each other to serve client needs. Wilen Media, a full-service direct marketing agency servicing Fortune 500 companies, that applies data strategy across all media; WILopEN engages in research and development efforts to create new products and services involving marketing, advertising, publishing/print and media-related businesses.

Source: Wilen Direct.

Source: http://www.piworld.com/article/direct-marketing-firm-wilen-direct-achieves-ssae-16-certification/1

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The First 7 Steps to a Successful Social Media Plan for Writers ...

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Source: http://writetodone.com/2012/11/27/the-first-7-steps-to-a-successful-social-media-plan-for-writers/

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Can Reality TV Boost Self-Control? | World of Psychology

Flipping through one of Psychology Today?s recent issues, my eyes focused on a short article ?Just Give In. Five Indulgences that actually boost self-control? by Kelly McGonigal, Ph.D.

What are these five indulgences? Personally, I was hoping chocolate was on the list. (Unfortunately, it?s not!) McGonigal narrows it down to these five things: a single espresso, an afternoon nap, a snack, YouTube and reality television.

The author writes that ?Willpower diminishes as the day wears on, but anything that reduces stress, boosts your mood, or recharges your energy can also reboot your self-control.?

Even ?reality TV??

Last night, after watching various contestants on a popular reality show sing for 90 minutes, I felt like falling asleep. Willpower? I must be watching the wrong program. Survivor might give me some energy: watching people trudge through swamps and sleep in tents, screaming at each other and falling in ?love? the next episode.

I kept reading, hopeful that the small paragraph devoted to the indulgence of reality television would explain our culture?s obsession with watching other people. People on a screen and not, say, upstairs in a different room or a phone call away.

?Willpower is contagious,? the author continues. ?Many reality shows feature people working hard to overcome obstacles as they lose weight, face their fears, or organize their clutter.?

I paused reading and recalled a past co-worker who spent, unfortunately, at least 30 minutes every single day talking about her favorite show, The Biggest Loser. We worked side-by-side and so this was particularly irritating, but even more so was the fact that she spent time talking to me ? and anyone else who would listen ? about her diets. She had a new diet every week and none of them worked.

I guess the show?s ?willpower? did not translate to her lifestyle. Sort of like how I can?t sing a note despite watching all of these silly singing shows.

The article concludes with ?You can ?catch? extra self-control just by watching someone pursue a goal.? Hmm. While the author of this article believes that television can boost willpower and productivity, I disagree. Watching television is a sedentary activity and it uses very few brain cells ? feeding your dog uses more. [Ed. - Although it may be a common popular perception, there's also little research that supports the idea that reality TV shows can help a person with their own willpower or act as a personal motivator.]

So, what?s the verdict? The reality is that watching reality television is a form of escape. I doubt it promotes ?self-control? (am I the only one who eats dinner while watching television?) but it has ingrained its way into our culture.

That aside, watching the presidential debates far exceeds the drama I have witnessed in any episode of Survivor. In the end, ?real life? is reality.

Reference

McGonigal, K. (2012, August). Just give in. Psychology Today, 45(4):13.

?

Woman with remote photo available from Shutterstock

????Last reviewed: By John M. Grohol, Psy.D. on 27 Nov 2012
????Published on PsychCentral.com. All rights reserved.

APA Reference
Champagne, N. (2012). Can Reality TV Boost Self-Control?. Psych Central. Retrieved on November 28, 2012, from http://psychcentral.com/blog/archives/2012/11/27/can-reality-tv-boost-self-control/

?

Source: http://psychcentral.com/blog/archives/2012/11/27/can-reality-tv-boost-self-control/

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Now Seeking Field Hockey Commissioner | Granville Recreation ...

Posted on November 28th, 2012 by Lara

The Granville Recreation District is seeking applicants for a field hockey commissioner (includes grades?5 ? for the 2013 fall season. Persons applying for this part-time paid position should have knowledge of the sport, be available evenings and weekends during the season, have good communication and organizational skills and enjoy working with volunteer coaches and youth player participants. Personal interview and background check will be required. Application deadline is December 28^th. For more information or to obtain an application, please call the GRD at 587-1976 or email us at?info@granvillerec.org.

>Download commissioner application here

Source: http://www.granvillerec.org/2861/now-seeking-field-hockey-commissioner/

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Free Christmas Advent Calendar iOS App for Christian Kids and ...

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Source: http://www.valmg.com/index.php/2012/free-christmas-advent-calendar-ios-app-for-christian-kids-and-schools/

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Acne in women can signal hormone problems - TODAY Health

By Rachael Rettner, MyHealthNewsDaily

Acne in adult women is common, but in some cases, it can signal an underlying hormonal disorder, experts say.

Identifying such cases is important, not only to better treat women's acne, but to correct hormone imbalances that can lead to other health problems, said Dr. Kanade Shinkai, a dermatologist at the University of California, San Francisco School of Medicine, who specializes in acne treatments.

However, doctors often simply give women prescriptions for acne treatments, such as antibiotics, which typically don't work for acne caused by hormone imbalances, Shinkai said

Women who visit the dermatologist for acne and who experience signs of a hormonal disorder, such as irregular periods, should discuss their symptoms with their doctors, Shinkai said.

In addition, it's important for dermatologists to conduct a thorough medical history of their patients so that they can identify hormonal disorders that manifest as acne, she said.

Acne in adult women is often hard to treat. One study showed that 80 percent of women prescribed antibiotics for acne receive no benefits from the drugs, Shinkai said.

In these cases, the acne may stem from normal hormonal changes, such as those that occur around the menstrual cycle, or from a true hormonal disorder. For many of these women, medications that target hormones, rather than skin bacteria, would provide the most help, Shinkai said.

Women with acne may have elevated levels of male hormones such as testosterone, Shinkai said. Symptoms of this type of hormonal imbalance include hair growth on the face, a deepening of the voice, increased muscle mass and decreased breast size.

The most common cause of such a hormonal change is a condition called polycystic ovarian syndrome, or PCOS. Women suspected of having a hormonal disorder can be diagnosed by having a doctor check their blood for elevated levels of male hormones, or in the case of PCOS, an ultrasound of the ovaries.

If a woman has PCOS or another type ofhormone imbalance, treating the underlying hormonal problem will help with the acne, Shinkai said.

Shinkai typically prescribes birth control pills to patients with PCOS, to lower their levels of male hormones. If those pills don't work by themselves, Shinkai adds another drug called spironolactone.

If left untreated, the hormone imbalances associated with PCOS may increase a woman's risk of cancer, as well as diabetes and obesity, which bring their own sets of medical problems, Shinkai said.

Birth control and spironolactone can also work very well against acne even in women with no hormonal disorder, Shinkai said.

More from MyHealthNewsDaily:

Source: http://todayhealth.today.com/_news/2012/11/27/15488631-acne-in-women-can-signal-hormone-problems

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Experts exhume remains of Palestinian leader

RAMALLAH, West Bank (AP) ? The remains of the late Palestinian leader Yasser Arafat were exhumed from his grave on Tuesday so international forensic experts could search for additional clues to his death, Palestinian officials said.

The remains were taken from the massive mausoleum in the West Bank city of Ramallah where Arafat was buried and moved to a nearby mosque so Palestinian doctors could take samples from his bones, the officials said. Under Islam, only Muslims can handle a Muslim's remains.

The samples will be handed over to French, Swiss and Russian experts who have flown in for the exhumation and who will examine them in their home countries, the officials said. Earlier, samples were also taken from Arafat's bedroom, office and personal belongings, they said.

The Palestinian officials spoke on condition of anonymity because they were not authorized to discuss the matter with the media.

The new investigation into Arafat's death was sparked earlier this year by the discovery of a lethal radioactive substance, polonium, on clothing said to be his.

Arafat died in November 2004 in a French military hospital, a month after suddenly falling ill. While the immediate cause of death was a stroke, the underlying source of an illness he suffered in his final weeks has never been clear, leading to persistent speculation in the Arab world that Israel poisoned him. Israel has denied such allegations.

The exhumation might not resolve the mystery. Polonium-210 decomposes rapidly, and some experts say it is not clear whether any remaining samples will be sufficient for testing.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2012-11-27-Palestinians-Arafat's%20Death/id-6b6e1ad6f8384000b1ccd190926d4592

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Egyptians gather at Tahrir for anti-Morsi protest

Egyptians carry a protester wounded in clashes with security forces near Tahrir square, where an opposition rally has been called for to voice rejection of President Morsi's seizure of near absolute powers, in Cairo on Tuesday, Nov. 27, 2012. The Health Ministry said more than 400 people have been wounded nationwide, including 49 who remain hospitalized, since the clashes erupted on Friday, according to a statement carried by the official news agency MENA. (AP Photo/Thomas Hartwell)

Egyptians carry a protester wounded in clashes with security forces near Tahrir square, where an opposition rally has been called for to voice rejection of President Morsi's seizure of near absolute powers, in Cairo on Tuesday, Nov. 27, 2012. The Health Ministry said more than 400 people have been wounded nationwide, including 49 who remain hospitalized, since the clashes erupted on Friday, according to a statement carried by the official news agency MENA. (AP Photo/Thomas Hartwell)

Egyptian security forces arrest a protester during clashes near Tahrir square in Cairo, Egypt, Tuesday, Nov. 27, 2012. Egyptian protesters and police clashed in Cairo on Tuesday just hours ahead of a planned massive rally by opponents of the country?s Islamist president demanding he rescinds decrees that granted him near-absolute powers.(AP Photo/ Khalil Hamra)

Egyptian security forces arrest a protester during clashes near Tahrir square, where an opposition rally has been called for to voice rejection of President Morsi's seizure of near absolute powers, in Cairo, Egypt, Tuesday, Nov. 27, 2012. Egyptian protesters and police clashed in Cairo on Tuesday just hours ahead of a planned massive rally by opponents of the country?s Islamist president demanding he rescinds decrees that granted him near-absolute powers.(AP Photo/ Khalil Hamra)

Egyptians carry a protester wounded in clashes with security forces near Tahrir square, where an opposition rally has been called for to voice rejection of President Morsi's seizure of near absolute powers, in Cairo on Tuesday, Nov. 27, 2012. The Health Ministry said more than 400 people have been wounded nationwide, including 49 who remain hospitalized, since the clashes erupted on Friday, according to a statement carried by the official news agency MENA. (AP Photo/Thomas Hartwell)

Egyptians clash with security forces and attempt to throw back tear gas canisters fired at them near Tahrir square, where an opposition rally has been called for to voice rejection of President Morsi's seizure of near absolute powers, in Cairo, Egypt, Tuesday, Nov. 27, 2012. The Health Ministry said about 444 people have been wounded nationwide, including 49 who remain hospitalized, since the clashes erupted on Friday, according to a statement carried by the official news agency MENA. (AP Photo/Thomas Hartwell)

CAIRO (AP) ? Thousands flocked to Cairo's central Tahrir square on Tuesday for a protest against Egypt's president in a significant test of whether the opposition can rally the street behind it in a confrontation aimed at forcing the Islamist leader to rescind decrees that granted him near absolute powers.

Waving Egypt's red, white and black flags and chanting slogans against President Mohammed Morsi and his Muslim Brotherhood, the protesters joined several hundreds who have been camping out at the square since Friday demanding the decrees be revoked.

Even as the crowds swelled, clashes erupted nearby between several hundred young protesters throwing stones and police firing tear gas on a street off Tahrir leading to the U.S. Embassy. Clashes have been taking place at the site for several days fueled by anger over police abuses, separately from the crisis over Morsi.

The president's declaration last week of new powers for himself has energized and ? to a degree unified ? the mostly liberal and secular opposition after months of divisions and uncertainty while Islamists from the Muslim Brotherhood and other groups rose to dominate the political landscape.

The turnout for Tuesday's protest call is key to whether the opposition can keep a movement going against Morsi. While the edicts last week sparked the protests, they have also been fueled by anger over what critics see as the Brotherhood's monopolizing of power after its election victories the past year for parliament and the presidency.

"We want to change this whole setting. The Brotherhood hijacked the revolution," said Rafat Magdi, an engineer who was among a crowd of around 2,000 marching from the Cairo district of Shubra to Tahrir to join the rally. "People woke up by his mistakes, and any new elections they will get no votes."

Morsi's decrees, issued Thursday, placed him above any kind of oversight, including that of the courts, until a new constitution is adopted and parliamentary elections are held ? a timeline that stretches to mid-2013.

The opposition says the decrees give Morsi near dictatorial powers by neutralizing the judiciary at a time when he already holds executive and legislative powers. Leading judges have also denounced the measures.

Morsi says the decrees are necessary to protect the "revolution" and the nation's transition to democratic rule. His declaration made all his decisions immune to judicial review and banned the courts from dissolving the upper house of parliament and an assembly writing the new constitution, both of which are dominated by Islamists. The decree also gave Morsi sweeping authority to stop any "threats" to the revolution.

By early afternoon, nearly 20,000 people were at Tahrir, birthplace of the 18-day popular uprising that toppled President Hosni Mubarak's authoritarian regime nearly two years ago. Security was tightened across Cairo, with police checking ID papers and searching cars coming into the center, but there was no sign of protesters being stopped from reaching Tahrir.

A chaotic city of some 18 million people, Cairo's traffic was uncharacteristically light on Tuesday, with many businesses and government offices closing shop early in anticipation of possible unrest.

A new banner in the square proclaimed, "The Brotherhood stole the country" and one protester, Mahmoud Youssef, said: "We are here to bring down the constitutional declaration issued by Morsi." Many chanted the iconic slogans "the people want to bring down the regime."

Several thousand lawyers meanwhile gathered outside their union building in downtown Cairo ahead of their march to Tahrir to join protesters there. "Leave, leave," they chanted, addressing Morsi, who narrowly won elections in June to become the country's first freely elected civilian president.

In the Mediterranean city of Alexandria, some 3,000 anti-Morsi protesters gathered outside the main court at the center of the ancient city.

Morsi's supporters canceled a massive rally they had planned for Tuesday, citing the need to "defuse tension" after a series of clashes between the two camps since the decrees were issued Thursday.

But a Brotherhood spokesman said demonstrations supporting the president could go ahead outside the capital and that supporters would form human chains in some provinces to protect Brotherhood offices. Morsi's supporters say more than a dozen of their offices have been ransacked or set ablaze since Friday. Some 5,000 demonstrated in the southern city of Assiut in support of Morsi's decrees, according to witnesses there.

On Monday, Morsi met with the nation's top judges and tried to win their acceptance of his decrees. But the move was dismissed by many in the opposition and the judiciary as providing no real concessions.

Presidential spokesman Yasser Ali, said Morsi told the judges that he acted within his rights as the nation's sole source of legislation, assuring them that the decrees were temporary and did not in any way infringe on the judiciary. He underlined repeatedly that the president had no plans to change or amend his decrees.

According to a presidential statement late Monday, Morsi told the judges that his decree meant that any decisions he makes on "issues of sovereignty" are immune from judicial review.

The vaguely worded statement did not define those issues, but they were widely interpreted to cover declaration of war, imposition of martial law, breaking diplomatic relations with a foreign nation or dismissing a Cabinet. Morsi's original edict, however, explicitly gives immunity to all his decisions and there was no sign it had been changed.

Monday's presidential statement Monday did not touch on the immunity that Morsi gave the constitutional assembly or the upper chamber of parliament, known as the Shura Council. It also did not affect the edict that the president can take any measures he sees as necessary to stop threats to the revolution, stability or public institutions. Many see that edict as granting Morsi unlimited emergency powers.

The Shura Council does not have lawmaking authorities but, in the absence of the more powerful lower chamber, the People's Assembly, it is the only popularly elected, national body where the Brotherhood and other Islamists have a majority. The People's Assembly was dissolved by a court ruling in June.

Rights lawyers and activists, however, dismissed Morsi's assurances as an attempt to defuse the crisis without offering concrete concessions.

One of the lawyers, Ahmed Ragheb, described the presidential statement and Ali's comments as "playing with words."

"This is not what Egyptians are objecting to and protesting about," he said. "If the president wanted to resolve the crisis, there should be an amendment to his constitutional declaration."

On Tuesday, the influential Judges' Club, a sort of union led by an outspoken Morsi critic, vowed in a statement to escalate its resistance to the decrees. The statement was carried by Egypt's official MENA news agency, which also reported that judges and prosecutors continued their strike for the third day Tuesday, leaving many courtrooms empty across the nation.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2012-11-27-Egypt/id-a6ac041046714e9eae4855c5ddb4373d

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Fertility: Putrescine water may be fountain of youth for human eggs

ScienceDaily (Nov. 26, 2012) ? An Ottawa scientist has discovered a critical reason why women experience fertility problems as they get older. The breakthrough by Dr. John? Liu, a senior scientist at the Ottawa Hospital Research Institute and professor at the University of Ottawa, also points to a simple solution that could increase the viability of egg cells for women in their late 30s and older -- putrescine water.

In an online editorial published by Aging based on his recently published findings, Liu outlines how a simple program of drinking water or taking a pill that contains the naturally occurring compound putrescine could reduce the rate at which middle-aged women produce eggs with the incorrect number of chromosomes, the leading cause of reduced fertility and increases in miscarriages and congenital birth defects.

Putrescine is naturally produced in mammals by an enzyme called ornithine decarboxylase, or ODC, and is easily absorbed and cleared by the body. In female mammals, ODC levels are known to rise during ovulation, when the egg cell matures and is released from the ovary. Dr. Liu has shown that ODC levels rise very little in older females. He has also shown that inhibiting ODC levels in young mice leads to an increase in egg cells with chromosomal defects.

Taking this a step further, Dr. Liu's team gave older mice putrescine water in the period immediately leading up to and during ovulation, and found that it reduced the incidence of defective eggs by more than 50%.

This is a remarkable outcome for such a simple approach," says Dr. Liu. "However, we could not have imagined this without first understanding the role that ODC and putrescine play in maintaining the chromosomal integrity of egg cells. While there is work to be done before it can be approved for clinical use, we feel this approach could be used for natural conception as well as in vitro fertilization."

Although promising, a putrescine pill is still a long way from being available on the market. Putrescine is toxic to the fetus if it is administered after conception, which makes timing, dosage and monitoring critical. Accordingly, this approach must go through the appropriate stages of testing to determine its clinical safety and effectiveness in humans.

The full paper, "Deficiency of ovarian ornithine decarboxylase contributes to aging-related egg aneuploidy in mice," was recently accepted for publication online ahead of print by Aging Cell. The editorial was published online by Aging on November 23. Yong Tao of the Ottawa Hospital Research Institute and the University of Ottawa is co-author on both publications.

Funding for this research was provided by a Discovery Grant from the Natural Sciences and Engineering Research Council of Canada and a partial scholarship from the Canadian Institutes of Health Research's Training Program in Reproduction, Early Development, and the Impact on Health.

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Story Source:

The above story is reprinted from materials provided by Ottawa Hospital Research Institute.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal References:

1. X. John? Liu and Yong Tao. Peri-ovulatory putrescine to reduce aneuploid conceptions. Aging, 2012 [link]
2. Yong Tao, X. John? Liu. Deficiency of ovarian ornithine decarboxylase contributes to aging-related egg aneuploidy in mice. Aging Cell, 2012; DOI: 10.1111/acel.12016

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/y_QE2EhZKSs/121126131124.htm

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Greg Mankiw On Warren Buffett - Business Insider

In a NYT Op-Ed today, Warren Buffett argued that the rich should pay a certain minimum tax, and he explained to activist Grover Norquist that it's preposterous to think that businessmen would forgo profitable deals merely because the rate of tax on the profits would go up.

But why do people listen to Buffett on taxes?

Basically because he's a rich, successful guy (which is why a lot of people are listened to on a lot of subjects).

To that end, economist and former Romney advisor Greg Mankiw has a short post talking about Buffett as a master of "tax avoidance," wherein he lists four things Buffett does to avoid paying taxes.

• Berkshire never pays a dividend (so the jump in dividend tax hikes don't effect him).
• Berkshire only trades long-term? (so short-term cap gains, which are taxed at income tax rates don't effect him).
• He's giving most of his money away to charity.
• His children won't pay income taxes on any assets that are bequeathed to them, so an income tax hike doesn't affect them.

None of these are wrong or illegal or anything. And giving your money away to charity is admirable. So the point isn't that Buffett is doing anything wrong, but that he's advocating policies which will have very little effect on him. So if we're going to listen to him because of who he is, it's not preposterous to note how little of an effect rule changes would have on him.

Other folks, in the past, have charged that Buffett specifically benefits from the tax proposals he backs.

Tim Carney of the Washington Examiner has pointed out:

Buffett regularly lobbies for higher estate taxes. He also has repeatedly bought up family businesses forced to sell because the heirs? death-tax bill exceeded the business?s liquid assets. He owns life insurance companies that rely on the death tax in order to sell their estate-planning businesses.

All that being said, the arguments against raising taxes marginally on the rich (assuming a deficit reduction deal is warranted) tend to be pretty poor.

For more on today's Op-Ed, see here >

Source: http://www.businessinsider.com/greg-mankiw-on-warren-buffett-2012-11

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hotfile downloads: Download Panda Security Products Pack 2012 free

Pandas products include security tools for home users and enterprises, including protection against cybercrime and kinds of malware that can damage IT systems, such as spam, hackers, spyware, dialers and undesirable web content, as well as detection of WiFi intrusions.

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If your computer is used by other people, you can put restrictions on the content they can access on the Internet. Configure the filters for each user and you wont have to worry about some users accessing inappropriate content.

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Panda Global Protection 2012

Protect yourself from all kinds of online threats: virus, hackers, online fraud, identity theft and all other known and unknown malware.

Keep your inbox spam-free and navigate safely and privately on the internet with the new Panda safe Browser. Your children will navigate safely on the Internet with the improved Parental Control, while the Panda Secure Vault will allow you to encrypt private folders and files or eliminate them forever.

Panda Global Protection is a complete computer protection solution that will enable you to secure your data and keep it safe from external threats.

Here are some key features of Panda Global Protection:

Anti-Malware Engine:

Automatically detects and eliminates viruses, spyware, Trojans, rootkits, bots and other malware before they infect your computer.

Scans files in real-time and on-demand

Scans emails before they reach your inbox, regardless of your email program.

Scans Internet traffic regardless of your browser type

Scans Instant Messaging traffic in MSN Messenger, Windows Live Messenger, Yahoo Messenger and AOL.

Removes all traces of clutter left by spyware on your PC.

Advanced Proactive Protection:

Technologies from Panda Security are widely recognized as the most effective against new and unknown malware.

Genetic Heuristic Engine combines advanced algorithms to detect new variants of the most dangerous malware families.

TruPrevent Technologies 2.0 silently analyze the behavior of programs, blocking those that try to damage your PC. This last line of defence blocks zero-day targeted attacks and terminates any malicious activity that has evaded traditional protection systems.

Personal Firewall:

Protects you against Internet-borne worms and hacker attacks.

Smart auto-configuration allows good programs to run while blocking malicious ones.

Shields your PC from hackers on the Web.

Wireless Monitor protects your wireless network from intruders.

Intrusion prevention blocks known and unknown hacker attacks and vulnerability exploits.

Identity Theft Protection:

Anti-Phishing Filter

Recognizes fraudulent email and protects you from scams while you shop, bank or pay bills online.

Anti-Banking Trojan Engine

Detects the most dangerous identity theft malware used by cyber-criminals to steal banking credentials. Specialized heuristics and generic detection techniques ensure maximum protection for online transactions.

Anti-Rootkit Technology:

Detects and removes silently-installed rootkits used by malware or hackers to evade traditional antivirus products.

Safe Internet Browsing

Anti-Spam Filter:

Keeps your inbox free from junk mail. With the new spam engine detection rates are now over 97%, ensuring uninterrupted service and delivering the emails you really need.

Parental Control:

Lets your children browse the Internet safely by blocking access to violent, adult, or racist content, as well as other inappropriate websites. From the solutions control panel and regardless of the browser type- you can assign predefined filters (child, adolescent, employee) to users or customize filter rules according to your specific needs.

Web Filter:

Lets you use the Internet safely without the risk of infections, vulnerability exploits, browser hijacking or phishing websites.By analyzing website content, links and Web reputation scores, Panda Security provides protection against all types of Web-based malware and scams.

Personal Information Filter:

Prevents theft from your PC of credit card numbers, social security numbers and any other personal information you define.

PC Optimization:

Backup & Restore

Safeguards your most important files against accidental loss or damage. It prevents loss of important documents either unintentionally, or through hard disk problems or other accidents. Backup and restoration from hard drive, CD, DVD, other external media or online are both extremely simple and easy.

Premium Online Backup:

To safeguard your most important files and have access to them anytime, anywhere. Backing up your most important files online ensures the integrity of your information regardless of what happens to your PC. This ultimate safety layer provides 2 gigabytes of free, secure storage for one year.

Tune Up:

Automatically finds and fixes problems in your PC and keeps your system running smoothly. It optimizes your PC performance by removing unnecessary registry entries, deleting temporary files and speeding up your hard disk.

Panda Antivirus Pro 2012

More than a simple Antivirus! Panda Antivirus Pro offers the easiest and most intuitive protection for your computer. Install it and forget about viruses, spyware, root kits, hackers and online fraud.

Chat, share photos and videos, do online shopping and banking, read your favorite blogs or browse the web with total peace of mind and without interruptions. Thanks to the Collective Intelligence technology, this product is safer, faster and more complete than ever.

Furthermore, Panda Antivirus Pro will offer maximum protection with minimum impact on your computer via its easy-to-use and intuitive interface.

Here are some key features of Panda Antivirus Pro:

Protection against spyware:

Protects your privacy by preventing spyware from being installed on your computer. The anti-spyware protection prevents this type of software from compiling data about your Internet habits and preferences.

Protection against unknown threats:

Thanks to the revolutionary TruPrevent Technologies now, more than ever, you will be protected against malware at all times.

Protection against all types of malware:

Not only are you protected against viruses. Now you have integrated protection capable of combating all types of malicious software: hacking tools, jokes, malicious cookies, viruses, etc.

Firewall:

Neutralizes network viruses and prevents possible intrusions or attacks by hackers trying to enter your computer through the Internet.

Protection against vulnerabilities:

Protects you against security holes in certain applications that could make your computer easy prey to all types of malicious software and hackers. Now you can fix vulnerabilities detected in your computer, giving you even greater security.

Services:

Enjoy the wide range of services that we offer. Now you have a whole team of IT security experts to help you resolve any queries that could arise. In addition, on our Web page, you can access the latest versions of our products and all the information you need.

Panda Internet Security 2012 for Netbooks

PROTECTION FOR YOUR NETBOOK (valid for all kinds of PCs)

Safely browse the Internet and chat with complete peace of mind. Protect against

viruses, online fraud, identity theft, unsolicited emails and cybercriminals.

Protection for your Netbook against all kind of threats

Protect your personal data against identity theft

Protect your communications against online fraud

Protect your networks against hackers and intruders

Panda Internet Security 2012 for Netbooks allows you to get the most of your Netbook for any offline or online activity, such as buying or banking online, with confidence and without interruption.

It protects you from viruses, hackers, online fraud, identity theft and other known and unknown threats, and keeps your mailbox free from spam.

Surf the Internet safely with Panda Safe Browser and block inappropriate content for your kids with Parental Control.

Maximum Protection

The Panda Cloud Technology offers a new protection model based on a user community where everyone contributes. Your computer will always be updated and protected. Additionally, your PC wont limit detection capabilities as Pandas huge virus detection database is located on the Internet (Cloud).

Minimum Impact

Panda Internet Security 2012 for Netbooks dramatically reduces resource consumption as the malware database is on the cloud, not in your PC. Also, its lightweight protection minimizes performance impact.

Easy to use

Its intuitive interface is perfect for all types of users. Access all the information that you need with just one click.

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